A group of researchers in Japan has achieved a new method of delivering drugs to the brain, which has appeared successful in experiments on mice. They say this method can slow down the progression of Alzheimer’s disease and maybe even provide hope for its cure.
Scientists in this method to transmit Amyloid B protein antibody They have created a type of glucosylated polymeric nanomicelle inside the brain, which are actually tiny hollow balls that can pass through the blood barrier of the brain of mice. This process is mediated by glucose transporter number 1 (GLUT1) and is intensified by increasing blood glucose levels.
Researchers in their experiments Polymer nanomicelles filled with pieces of antibody against amyloid B oligomers and sent to the brains of Alzheimer’s mice. Nobu Sanjo, one of the senior researchers of this research, says: “The results were very clear. Injection of antibody fragments against amyloid B oligomers through polymeric nanomicelles significantly reduces the number of dangerous amyloid B species. Decrease gave In addition, the amyloid plaques that continued to form Smaller and less dense They were among the samples observed in other mice with Alzheimer’s.”
What was the effect of this treatment on mice with Alzheimer’s disease?
The researchers then examined the behavior of the treated mice and found that these mice Learning and memory capacity have been better than untreated mice. Akiko Amano, one of the senior authors of this paper, says: “Our findings show that delivering a suitable level of antibody to the brain with the help of polymer nanomicelles can reduce the dangerous species of amyloid B and The speed of Alzheimer’s progression lower the door to the rats.”
Alzheimer’s disease, which leads to dementia, is usually caused by the accumulation of amyloid B protein in the brain. In the past, scientists have tried to send antibodies against this protein to the brain, but these drugs do not effectively cross the blood-brain barrier. Now scientists have found new hope to help patients. The results of the current research have been published in the Journal of Nanobiotechnology.
